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Fine & Speciality Chemicals

Fine & Speciality Chemicals White Papers

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HPMC-LACTOSE MIXTURES AS MATRIX FORMERS IN CONTROLLED RELEASE TABLETS: PHYSICAL MIXTURES VS. CO-PROCESSED BLENDS
| By MEGGLE
The main objective of this work was to investigate the effects of the type of preparation method of HPMC/lactose-based matrix tablets on the resulting: 􀂃flowability and compressibility of the powders/granules 􀂃drug release kinetics 􀂃dimension changes 􀂃water uptake/weight loss kinetics of the tablets upon exposure to different release media.
Production & Manufacturing > Fine & Speciality Chemicals > White Papers
Powder Flow Investigated by Different Methods, and its Relation to Functional Performance as Demonstrated by Examination of Lactose and Lactose-Based Excipients
| By MEGGLE
The scope of this work is to compare routinely used, often historically-based flow assessment techniques as well as newer methods, including, but not limited to, Carr's Index, Hausner Ratio, Angle of Repose, flow through an orifice, weight uniformity, and powder rheometry with regard to validity and reproducibility, focusing on a frequently used excipients and proposing the best choice of a flow method with respect to predictability of functional performance.
Production & Manufacturing > Fine & Speciality Chemicals > White Papers
Predicting Drug Release Fom HPMC/lactose Tablets
| By MEGGLE
Three mathematical models were applied to quantify drug release from HPMC/lactose-based matrix tablets loaded with varying amounts of theophylline: (i) a numerical model considering drug diffusion in axial and radial direction in cylinders as well as limited drug solubility effects, (ii) an analytical solution of Fick’s second law of diffusion considering axial and radial mass transport in a cylinder, but neglecting limited drug solubility effects, and (iii) a simple early time approximation of the analytical solution, considering only radial mass transport and neglecting axial diffusion as well as limited drug solubility effects.
Production & Manufacturing > Fine & Speciality Chemicals > White Papers
A Simple Mathematical Model Allowing for the Prediction of Drug Release from HPMC/Lactose-Based Controlled Release Matrix Tablets
| By MEGGLE
To use a simple mathematical model to quantify drug release from matrix tablets based on RetaLac®: a co-processed blend of 50% hydroxypropyl methylcellulose (HPMC) and 50% lactose monohydrate (mechanically inseparable). To use the model to quantitatively predict the impact of the formulation design on the resulting release kinetics and to evaluate the reliability of these simulations by independent experiments.
Production & Manufacturing > Fine & Speciality Chemicals > White Papers
Enyzme Application Table
| By Johnson Matthey Fine Chemicals
Johnson Matthey Catalysis and Chiral Technologies provides an extensive set of biocatalysts providing a focused library resulting in quicker screening and maintaining a high hit rate standard. Every enzyme in our kit is 100% reproducible and available at commercial scale. More details on the reactions and products can be found online at: www.jmcct.com
Production & Manufacturing > Fine & Speciality Chemicals > White Papers
Need Help Choosing a Heterogeneous Catalyst? (North America)
| By Johnson Matthey Fine Chemicals
Johnson Matthey Catalysis and Chiral Technologies Heterogeneous Catalysts Application Table.
Production & Manufacturing > Fine & Speciality Chemicals > White Papers
Need Help Choosing a Heterogeneous Catalyst? (Europe)
| By Johnson Matthey Fine Chemicals
Johnson Matthey Catalysis and Chiral Technologies Heterogeneous Catalysts Application Table.
Production & Manufacturing > Fine & Speciality Chemicals > White Papers
Chiral Homogenous Catalysts Applications Table
| By Johnson Matthey Fine Chemicals
Johnson Matthew Catalysis and Chiral Technologies provides an extensive set of chiral homogeneous catalysts for a wide range of applications. The catalysts are grouped in six classes, sharing common application scope as reported in the table below.
Production & Manufacturing > Fine & Speciality Chemicals > White Papers
Catalyst Screening and Process Development Services
| By Johnson Matthey Fine Chemicals
At Johnson Matthey we focus on the chemistry with an expectional choice for the best catalytic technology. We have hundreds of different catalysts available:
Production & Manufacturing > Fine & Speciality Chemicals > White Papers
Production of Biologics out of Traditional Expression Systems
| By Sanofi CEPiA
Within Sanofi Industrial Affairs we can offer external partners looking for a CDMO / CMO (contract development and manufacturing organization / contract manufacturing organization) the excellence of our industrial network to produce custom APIs. We are able to provide customers with GMP material from clinical stage to commercial scale.
Production & Manufacturing > Fine & Speciality Chemicals > White Papers
Highly Active Pharmaceutical Ingredients
| By Sanofi CEPiA
A key activity is the manufacturing of highly active pharmaceutical ingredients (HAP) and cytotoxic compounds. This activity stems from Sanofi’s expertise gained through the manufacturing of taxanes (Docetaxel, Taxotere® and Cabazitaxel, Jevtana®) and in the development of other drugs for oncology. CEPiA is glad to present to customers its dedicated equipment and facilities for highly active products manufacturing.
Production & Manufacturing > Fine & Speciality Chemicals > White Papers
Signed by Syncom - Designing Chemistry in 25 Milestones
| By Syncom BV pbr
There are so many reasons to be proud of this company. In the first 25 years of Syncoms’ existence, we have truly made a contribution to science, the pharmaceutical industry, the health of many people across all continents, to the economy of our city (Groningen), as well as to the careers and lives of employees and former employees.
Production & Manufacturing > Fine & Speciality Chemicals > White Papers
Peptides and Oligonucleotides
| By Sanofi CEPiA
From a unique state-of-the-art platform for development and scale-up of Peptides and Oligonucleotides, CEPiA offers customised manufacturing and analytical services and development activities from clinical phase, up to submission and launch, as well as regulatory support and commercial supplies.
Production & Manufacturing > Fine & Speciality Chemicals > White Papers
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