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Powder Flow Investigated by Different Methods, and its Relation to Functional Performance as Demonstrated by Examination of Lactose and Lactose-Based Excipients

Published 14 January 2015 | By MEGGLE

The scope of this work is to compare routinely used, often historically-based flow assessment techniques as well as newer methods, including, but not limited to, Carr's Index, Hausner Ratio, Angle of Repose, flow through an orifice, weight uniformity, and powder rheometry with regard to validity and reproducibility, focusing on a frequently used excipients and proposing the best choice of a flow method with respect to predictability of functional performance.

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Powder Flow Investigated by Different Methods, and its Relation to Functional Performance as Demonstrated by Examination of Lactose and Lactose-Based Excipients