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MODELING DRUG RELEASE FROM RETALAC® TABLETS: IMPACT OF DRUG SOLUBILITY

Published 14 January 2015 | By MEGGLE

Hydrophilic matrices are frequently used to control drug release from oral solid dosage forms. Recently, RetaLac®, a co-processed blend of 50% hydroxypropyl methylcellulose and 50% lactose monohydrate (mechanically inseparable) has been marketed. RetaLac® can be used to prepare matrix tablets by direct compression. However, yet little is known on the underlying drug release mechanisms from this type of dosage forms.

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MODELING DRUG RELEASE FROM RETALAC® TABLETS: IMPACT OF DRUG SOLUBILITY