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HPMC-LACTOSE MIXTURES AS MATRIX FORMERS IN CONTROLLED RELEASE TABLETS: PHYSICAL MIXTURES VS. CO-PROCESSED BLENDS

Published 14 January 2015 | By MEGGLE

The main objective of this work was to investigate the effects of the type of preparation method of HPMC/lactose-based matrix tablets on the resulting: 􀂃flowability and compressibility of the powders/granules 􀂃drug release kinetics 􀂃dimension changes 􀂃water uptake/weight loss kinetics of the tablets upon exposure to different release media.

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HPMC-LACTOSE MIXTURES AS MATRIX FORMERS IN CONTROLLED RELEASE TABLETS: PHYSICAL MIXTURES VS. CO-PROCESSED BLENDS